AI challenges fundamental concepts such as the human and the machine. Myth, metaphor, and generally the languages of art and literature as well as philosophy can be helpful in thinking through the challenges of AI when the languages of science, technology and commerce fail. The paper examines the enduring value of Mary Shelley’s Frankenstein in considering the questions of AI. The impact of AI upon human agency is also discussed. Without ways of thinking about, and grappling with a phenomenon as far reaching and transformative as AI, humans risk unintended, unforseen and perhaps unwelcome consequences of their technologies.